The problem of infertility occurs frequently and is always up-to-date.

Internationally, 15% of couples have difficulty in conceiving in general or in conceiving the desired number of children, according to World Health Organization (WHO). The probability of conception in a couple of reproductive age is 20% per month.

The rate of infertility remains stable over the centuries. In the 19th century, a study conducted in England, had showed that 1 out of 6 marriages weren’t reproductive (16%).

It is difficult to calculate accurately the percentage of infertile couples, because it requires a range of parameters and the exclusion of people who have been sterilized or use a contraceptive method but also those who do not wish to be conceived. In the US, there are approximately 10-15 million infertility couples, and 585,000 in Germany (1989 data). In Greece, there are approximately 300,000 couples.

This rate is stable in the last two decades, but the number of patients undergoing infertility treatment and the number of new fertility centers increase significantly.