According to the revised terminology of the International Society for Mild Approaches in Assisted Reproduction (ISMAAR), mild stimulation protocols include a) the natural cycle, b) modified natural cycle, and c) mild stimulation.

Mild ovarian stimulation involves the administration of a low dose of FSH (up to 150 IU/day) for a shorter duration, aiming at the development of fewer follicles and the collection of up to 7 oocytes. Mild stimulation protocols mainly use GnRH antagonists.

However, the use of mild stimulation protocols remains low, mainly because they require a sound knowledge of the GnRH antagonist protocol and optimal laboratory conditions.

At Eugonia we successfully use mild protocols for ovarian stimulation with specific criteria, taking into account the history of each individual couple.