It is usually used after embryo transfer to hormonally support the luteal phase of the menstrual cycle. According to the literature, the luteal phase of the menstrual cycle needs progesterone support, especially in treatment cycles that a GnRH analogue has been used.

This hormone is available in the form of a vaginal gel (Crinone), or in pills (Utrogestan). These pills may be administered orally, vaginally (as suppositories), or both orally and vaginally. The local absorption of progesterone from the vagina is very good and has proven to have excellent results.