We achieved a significant reduction in the development of severe hyperstimulation syndrome (OHSS) in women with polycystic ovaries, according to our recent publication, which is the world's largest study of its kind.

In addition, in a recent publication which is the world's largest in regard with the number of patients with polycystic ovarian syndrome (PCOS), we showed that the use of a flexible GnRH antagonist protocol leads to a statistically significant reduction in the development of severe ovarian hyperstimulation syndrome (OHSS) by 20%, when compared with the long protocol, without simultaneous reduction of pregnancy rates (Lainas et al., 2010).